Clarksdale is a city in and the county seat of Coahoma County, Mississippi, United States. It is located along the Sunflower River. Cl…Clarksdale is a city in and the county seat of Coahoma County, Mississippi, United States. It is located along the Sunflower River. Clarksdale is named after John Clark, a settler who founded the city in the mid-19th century when he established a timber mill and business. Clarksdale is in the Mississippi Delta region and is an agricultural and trading center. Many African-American musicians developed the blues here, and took this original American music with them to Chicago and other northern cities during the Great Migration.
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