The turning on of this single gene results in an apparent freak of nature. Mice whose agouti gene is "on" are also more likely to suffer from diabetes and cancer as adults. The implications of ...

Changes to melanin production created a golden mouse rather than the black/agouti wild type coat color ... ‘We’ve proven our ability to recreate complex genetic combinations that took nature ...

Loss-of-function mutations in the gene (CSTB ... that 45% (37/82) of agouti offspring were heterozygous for the insertion. We subsequently intercrossed these heterozygous mice.