Which genes are required for turning embryonic stem cells into brain cells, and what happens when this process goes wrong? In a new study published today in Nature Neuroscience, researchers led by ...

By editing thousands of genes in mouse stem cells, the scientists identified a list of over 300 that are crucial for neural differentiation.

“While recent single-cell multiomics studies and CRISPR screens in murine NK cells have expanded our understanding, actionable genomic targets in primary human NK cells have remained largely ...

Widely used as a genome editing tool, the CRISPR-Cas9 system allows researchers to precisely induce frameshift mutations in specific genes or insert foreign nucleic acid sequences into a cell’s DNA.

This article and associated images are based on a poster originally authored by Wambeke E, Boribong BP, Sinha H, Patel M, Vo PQN, Chin AB, Ellouzi A, Barlan K and Hirukawa A and presented at ELRIG ...

Moreover, the CRISPR-based CDKN2A knockout cells provide a renewable source of muscle progenitors, reducing dependence on repeated animal biopsies. Together, these innovations mark a critical step ...