Mitochondrial respiratory complexes (Complexes I–V) and their assembly into respiratory supercomplexes (SCs) are fundamental to liver bioenergetics, redox homeostasis, and metabolic adaptability.

The central vein (CV) region, driven by the Wnt signaling pathway, and the portal vein (PV) region, driven by the Notch signaling pathway, enable us to construct a biomimetic liver lobule ...

Organoids refer to small-scale organs made up of diverse cell types, exhibiting structures and functions akin to actual organs. Unlike conventional cell cultures, organoids better replicate human ...

The liver is the body's control tower for metabolism, powering vital functions like converting nutrients to glucose, storing fat and breaking down toxins. Over a third of the world, however, is ...

Liver disease, due to viral infections, alcohol abuse, obesity, or cancer, accounts for 1 in every 25 deaths worldwide. A liver transplant can be life saving for people with end-stage liver disease.

A team of researchers has uncovered a previously unknown compensatory mechanism found in liver disease. If Kupffer cells (KCs), a specific kind of immune cells found in the liver, become impaired by ...