Cachexia is a common complication of cancer and is associated with an increased risk of death. The level of growth differentiation factor 15 (GDF-15), a circulating cytokine, is elevated in cancer ...
In a recent study published in Nature Communications, researchers evaluate the impact of tumor-derived growth and differentiation factor-15 (GDF-15) on leukocyte function-associated antigen 1 ...
SGNTGT-001: A phase 1 study of SEA-TGT, an effector-function enhanced monoclonal antibody (mAb), in advanced malignancies (trial in progress). Background: Growth and differentiation factor 15 (GDF-15) ...
First report to show link between GDF-15 and LFA-1/ICAM-1 cell adhesion axis in cancer, resulting in impaired infiltration of T cells into the tumor microenvironment First report to show link between ...
Phase 2 clinical study evaluating the efficacy and safety of disitamab vedotin with or without pembrolizumab in patients with HER2-expressing urothelial carcinoma (RC48G001). Background: Neoadjuvant ...
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