In the late 1970s, glycogen synthase kinase-3 (GSK3) was identified as a protein kinase that inactivates glycogen synthase, but was ignored as a drug target by the pharmaceutical industry until the ...

Credit: Getty Images. Pompe disease is a rare, degenerative muscle disorder caused by mutations in the acid alpha-glucosidase gene, which leads to the abnormal buildup of glycogen. The Food and Drug ...

Clinical activity of avapritinib in ≥ fourth-line (4L+) and PDGFRA Exon 18 gastrointestinal stromal tumors (GIST). This is an ASCO Meeting Abstract from the 2020 Gastrointestinal Cancers Symposium.