Novel approach to the development of effective H5N1 influenza A virus vaccines: use of M2 cytoplasmic tail mutants. Journal of Virology, 82. 5: 2486-2492. RELATED TOPICS. Health & Medicine.

Universal protection against influenza viruses by multi-subtype neuraminidase and M2 ectodomain virus-like particle. PLOS Pathogens , 2022; 18 (8): e1010755 DOI: 10.1371/journal.ppat.1010755 Cite ...

We examined a total of 415 isolates of influenza A virus, sampled from November 2005 to April 2006 ... (H3N2) viral isolates (65.3%) were amantadine resistant, with a Ser31Asn change in the M2 ...

The influenza A M2 proton channel is a critical membrane protein facilitating proton conduction essential for viral uncoating and replication. Its capacity to conduct protons across the viral ...

Until recently, the pH-gated proton channel of influenza A virus, M2, was effectively targeted by amantadine-based antivirals, but resistance to these drugs is now widespread. Two groups now ...

The M2 inhibitors proved effective for prophylaxis against influenza illness in the 1968 pandemic of “Hong Kong influenza” and in the 1977 pandemic-like event involving “Russian influenza.” ...

A new PEARLS article in PLoS Pathogens reviews the rapid evolution and pandemic potential of emerging influenza A viruses, with a focus on H5N1. It highlights scientific advances and future ...

This colorized electron microscope image released by the National Institute of Allergy and Infectious Diseases on March 26, 2024, shows avian influenza A H5N1 virus particles, shown in yellow ...

The US Department of Health and Human Services is terminating a contract with drugmaker Moderna to develop a vaccine to protect against bird flu amid the agency’s broader efforts to reevaluate ...