Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 16 (April 19, 2022), pp. 1-10 (10 pages) A hallmark of pancreatic tumors is their highly desmoplastic ...

Sepsis is a fatal syndrome characterized by life-threatening organ dysfunction originating from a chaotic and unchecked innate immune response to infection. Notably, macrophages are the master ...

A positively-charged dextran nano-photosensitizer (p-Dex PS) facilitates TAM-mediated delivery and sublethal light-induced metabolic reprogramming, which boost the TAM polarization and subsequently ...

Sepsis, a complex syndrome driven by a dysregulated host response to infection, is closely linked to both metabolic and ...

Switching off a single enzyme in immune cells protected mice from obesity, type 2 diabetes, and fatty liver disease in a new study, offering a potential new treatment target for metabolic disorders.

Tumor growth unfolds within a tumor microenvironment (TME) defined by metabolic–immune crosstalk. Emerging evidence indicates that cancer cells not only reprogram glycolysis but also alter amino acid, ...

Georgetown University's Lombardi Comprehensive Cancer Center researchers have identified a new way to reprogram T cells, ...

Cancer cells survive therapy by dynamically rewiring their metabolism in response to nutrient availability, ...

Cancer represents a key challenge in medical science, manifesting as a disease where the immune system fails to recognize and eliminate tumor cells. The phenomenon of immune evasion by cancer cells ...