St. John's will try to defy the odds as a No. 2 seed when the NCAA Tournament 2025 gets underway. Second-seeded teams have been upset by No. 15 seeds three times in the last four years, most recently with No.

Whether you're cheering for your favorite team or making a bracket for fun, here's what you need to know about March Madness 2025.

According to Bet MGM, the four championship favorites are, naturally, the four No. 1 seeds: Duke (+325), Florida (+325), Auburn (+400) and Houston (+600). The fifth choice on the board is No. 2 seed Alabama, sliding down significantly to +1600. Tennessee checks in at +1800, and every other option is +2500 or higher.