The biggest favorites of Week 14 are the Seattle Seahawks (-7.5 at the Atlanta Falcons), Tampa Bay Buccaneers (-8.5 vs. the Saints), Denver Broncos (-7.5 at the Raiders) and Rams (-7.5 at the Arizona Cardinals).

Week 10 of the NFL season kicks off with an AFC West showdown on Thursday night as the Denver Broncos host the Las Vegas Raiders. And that's just the start of the division rivalry slate this week. The Cardinals will hope this is finally the week Kyler Murray returns to the starting lineup after a foot injury kept him limited ahead of Week 9.

The 49ers are 5.5-point favorites, according to the latest Browns vs. 49ers odds. The over/under for total points scored is 35.5, down seven from the opening line. The 49ers are -257 money line favorites (risk $257 to win $100),

The Browns will welcome the 49ers to Cleveland on Saturday. With winter in full swing, conditions are going to be tough at Huntington Bank Field. Weather forecasters are calling for morning rain to change over to snow showers in the afternoon near game time.

Can the Browns win in Shedeur Sanders' first NFL home start against the San Francisco 49ers? How did the Beacon Journal writers predict the game?

That's a five-day stretch where we'll have some variety of the NFL for four days. What a time to be alive! The only thing that pairs better with football than Thanksgiving is gambling. These matchups are as juicy as the turkey we're all about to eat later this week,

Sitting at 8-4 going after the win, the Chargers have a 62% chance of making the postseason, according to The Athletic's Playoff Simulator. They entered Week 13 with a 64% chance. The Texans' win over the Colts slightly reduced their odds. Los Angeles is in a three-way tie with the Colts and Bills, both 8-4.