Clemson and NC State face off in this ACC opener on Saturday in college football’s Week 4 action. Here’s what you need to know, along with our updated game prediction. Clemson pounded Appalachian State in a 66-20 result two weeks ago,

Both teams are preparing for their first conference matchup of 2024, with the Wolfpack winning two of the last three meetings since 2021, including a 24-17 victory last year. However, oddsmakers favor Clemson, and USA TODAY Sports’ six-member panel unanimously predicted a Tiger win.

NC State will be hard-pressed to move the chains vs. this Clemson defense in Death Valley, but Cade Klubnik & Co. won't be afraid to run up the score both early and late.