What's the difference between mRNA and pre-mRNA? It's all about splicing of introns. See how one RNA sequence can exist in nearly 40,000 different forms.

Heidelberg biochemists and structural biologists from Shanghai unravel the roles of two key regulatory factors in mRNA ...

How does the splicing machinery distinguish between exons, which are part of the mature mRNA, and introns, which are removed from the pre-mRNA? Alternative splicing adds an extra layer of ...

Research into splicing mechanisms and patterns is essential for decerning fundamental biological principles, as well as clarifying the molecular basis of many diseases and developing new therapies. 2 ...

Two molecular control factors play a decisive role in what is known as splicing, the cutting and assembly of mature messenger ...

Mutations (blue) in U2 snRNA cause a neurodevelopmental disorder about one-fifth as common as the RNU4-2/ReNU disorder, which ...

"Previously, we tended to think of splicing as a constant—you make a pre-mRNA; you splice it. Now we know that the physical ...

Mutations (blue) in U2 snRNA cause a neurodevelopmental disorder about one-fifth as common as the RNU4-2/ReNU disorder, which is linked to mutations (orange) in U4 snRNA. snRNAs are shown in black, ...

They succeeded once they were able to isolate the splicing complexes of the fungus that were in the midst of quality control ...