All PKU probands had the classical phenotype according to standard criteria [] and were not known to be related to one another.We analyzed 24 chromosomes from 12 PKU probands cared for at the ...

Table 4 Recombination on chromosome 12 between siblings with untreated PKU Full size table The TH gene was chosen as a candidate modifying gene because it can perform the same reaction as PAH and ...

PKU or Phenylketonuria is a genetically inherited condition.PKU occurs due ... The segment that contains the blue print coding for the enzyme phenylalanine hydroxylase lies in the 12 th chromosome.

PKU is now well documented in medical circles, ... The disorder is passed on to one in four children when both parents carry a defective gene on chromosome pair No.12.