Novel approach to the development of effective H5N1 influenza A virus vaccines: use of M2 cytoplasmic tail mutants. Journal of Virology, 82. 5: 2486-2492. RELATED TOPICS. Health & Medicine.

Universal protection against influenza viruses by multi-subtype neuraminidase and M2 ectodomain virus-like particle. PLOS Pathogens , 2022; 18 (8): e1010755 DOI: 10.1371/journal.ppat.1010755 Cite ...

We examined a total of 415 isolates of influenza A virus, sampled from November 2005 to April 2006 ... (H3N2) viral isolates (65.3%) were amantadine resistant, with a Ser31Asn change in the M2 ...

The M2 inhibitors proved effective for prophylaxis against influenza illness in the 1968 pandemic of “Hong Kong influenza” and in the 1977 pandemic-like event involving “Russian influenza.” ...

Until recently, the pH-gated proton channel of influenza A virus, M2, was effectively targeted by amantadine-based antivirals, but resistance to these drugs is now widespread. Two groups now ...

The influenza A M2 proton channel is a critical membrane protein facilitating proton conduction essential for viral uncoating and replication. Its capacity to conduct protons across the viral ...

A new PEARLS article in PLoS Pathogens reviews the rapid evolution and pandemic potential of emerging influenza A viruses, with a focus on H5N1. It highlights scientific advances and future ...