Dysregulated complement pathways are linked to progression from iAMD to advanced AMD, including NVAMD and GA. Higher systemic levels of C4, C4b, and a reduction in C3 are associated with increased ...

The following is a summary of “Complement is increased in treatment resistant rectal cancer and modulates radioresistance.,” published in the September 2024 issue of Oncology by O’Brien et al.

Complement proteins, especially when activated in the brain and spinal cord, may contribute to nerve cell damage and more severe multiple sclerosis (MS) symptoms, a study that offers insights into a ...

Complement may drive the pathology of hypertension through effects on innate and adaptive immune responses. Recently an injurious role for the anaphylatoxin receptors C3aR (complement component 3a ...

Backgrounds: Right ventricular (RV) failure plays a critical role in right heart failure and left heart failure. However, there is no specific therapy developed for RV failure. To elucidate a novel ...

The authors have declared no conflicts of interest. Several diseases are related to complement involvement. In particular, its role is essential for the pathogenesis of several renal disease. On the ...

The complement system identifies and eliminates pathogens and dying cells, 3 pathways can activate the complement system—classical, lectin, and alternative—and their activation results in similar ...

Despite advances in acute care, ischemic stroke remains a significant cause of long-term disability. Approaches targeting neuronal and glial responses are needed to enhance recovery and improve ...

Every year, more than 795,000 people in the US suffer a stroke. About 87% of these are ischemic strokes, in which the blood flow to the brain is blocked. The medical condition is a leading cause of ...

The following is a summary of the “Plasma complement C3 and C3a are increased in major depressive disorder independent of childhood trauma” published in the November 2022 issue of Psychiatry by Luo et ...