The Flagship Pioneering spinout uses permanent bonds to target shallow pockets, drastically expanding the druggable universe for small molecules.
The paradigm in nutritional science is shifting from studying isolated nutrients to understanding the complex food matrix.
Thousands of proteins are known to cause disease, but while the biological activity of these proteins is understood, the way to hit and modulate them with a drug is not. Nature still has ways to bind ...
Chronic kidney disease (CKD) involves intricate pathological mechanisms that currently lack definitive therapeutic interventions to halt disease progression. Increasing evidence suggests that ...
Researchers at Baylor College of Medicine have developed an artificial intelligence (AI) model that reveals how protein modifications link genetic mutations to disease. The method, called DeepMVP and ...
Extensive computational and experimental studies have aimed to deepen our understanding of the pathways by which proteins fold. However, the short-lived nature of folding intermediates has severely ...
Cognitive tasks, such as learning and memory, require rapid changes to proteins at synapses, such as protein synthesis, degradation, and trafficking. How protein post-translational modifications ...
Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. The chemical modification of proteins is one of the major mechanisms used to regulate ...
Article subjects are automatically applied from the ACS Subject Taxonomy and describe the scientific concepts and themes of the article. In this review, we discuss both historical and recent advances ...
Covalent modifications provide a precise and effective mechanism to regulate the biogenesis, stability, and function of biological molecules, including DNA, RNA, proteins, and lipids. More than 300 ...
Virology researchers have found that a specific protein modification to the immune protein MDA5 is key to how our bodies detect and respond to viruses and viral replication. The publication explains ...
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