Aro Biotherapeutics Reports Preliminary Efficacy for ABX1100, a Muscle-targeted GYS1 siRNA, in Patients with Late-Onset Pompe Disease (LOPD)

Aro Biotherapeutics, a clinical-stage biotechnology company developing potent and tissue-targeted short-interfering RNA (siRNA) medicines, today announced interim data from a phase 1b study of ABX1100 ...
European Medical Journal

Targeting Beta Catenin Degradation in B Cell Leukaemia

Researchers identify beta catenin protein degradation as a therapeutic vulnerability in B cell acute lymphoblastic leukaemia, supporting the repurposing of glycogen synthase kinase 3 beta inhibitors.
BioWorld

Harmine-based compounds emerge as brain-penetrant GSK-3β inhibitors

The serine/threonine kinase glycogen synthase kinase-3β (GSK-3β) plays a multifunctional role through its involvement in ...
eLife

Glycogen Engineering Improves the Starvation Resistance of Mesenchymal stem cells and their Therapeutic Efficacy in Pulmonary Fibrosis

This important study presents a novel approach to enhance the therapeutic potential of mesenchymal stromal cells (MSCs) by genetically modifying their glycogen synthesis pathway, resulting in ...
Cancer Research

Elraglusib, a Glycogen Synthase Kinase 3β Inhibitor, plus Chemotherapy with or without Immunotherapy in Patients with Recurrent, Metastatic Salivary Gland Carcinoma

1Center for Head and Neck Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. *Corresponding Author: Glenn J. Hanna, Dana-Farber Cancer Institute, 450 Brookline Avenue, Dana building 2nd ...
eLife

Glycogen Engineering Improves the Starvation Resistance of Mesenchymal stem cells and their Therapeutic Efficacy in Pulmonary Fibrosis

MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Tsinghua University, Beijing, China School of Life Sciences, Tsinghua University, Beijing, China Xinjiang Stem Cells ...
Bellevue Reporter

Glycogen X Glyco Optimizer – Natural Blood Sugar Stabilizer with Clean, Science-Backed Ingredients for Healthy Weight Loss

In today’s fast-paced world, maintaining optimal health can be a daunting task, especially for those struggling with weight management and blood sugar levels. Enter Glycogen X Glyco Optimizer, a ...
C&EN

Novel Tricyclic Compounds as GSK3 Inhibitors

This patent highlight describes a series of novel tricyclic system-based compounds as glycogen synthase kinase 3 (GSK3) inhibitors. The inhibitory potency of these compounds against GSK3α and GSK3β ...