Among members of the Richardson family who carry a mutation in the PSEN1 gene, the average age when symptoms start is 39.

Disease is one of the primary factors affecting life activities, with complex etiologies often influenced by gene expression and mutation. Currently, wet lab experiments have analyzed the mechanisms ...

In turn, the impact of mutations on dissociation kinetics can influence the receptor signaling bias, i.e., whether GPCR-mediated signaling preferentially evokes the G-protein pathway or the β-arrestin ...

For more information about the Phase 1/2 clinical trial, please visit www.clinicaltrials.gov (NCT07011771). About Parkinson’s disease associated with GBA mutations (PD-GBA) ...

Protein redesign is an enzyme engineering strategy that enhances a template enzyme’s properties by introducing mutations. Although the method is broadly employed for enzyme design, finding optimal ...