49ers' Isaac Guerendo: On field for OTAsGuerendo (knee/ankle) was an active participant at voluntary OTAs, per the 49ers ' official site. Guerendo sustained MCL and ankle sprains in his left leg ...

RotoBaller Ranking (half-PPR): RB53 Fantasy Draft Analysis: Isaac Guerendo saw time as the 49ers' RB1 while filling in for Christian McCaffrey and Jordan Mason last year. The sophomore rusher is a ...

2025 Outlook: Isaac Guerendo 2025 fantasy player outlook for Isaac Guerendo, RB, San Francisco 49ers By CBS Sports Staff Jun 10, 2025 at 5:56 am ET • 1 min read ...

The 49ers also have intriguing depth behind their All-Pro back. Second-year running back Isaac Guerendo stepped up in 2024, filling in admirably while McCaffrey and Jordan Mason battled injuries.

Guerendo, who got one carry those first three games McCaffrey was back, eventually ended his rookie season getting carted off Arizona’s field with an MCL injury.

Williams did not take part in team drills last Thursday. 7. Christian McCaffrey/Isaac Guerendo This is essentially a brand-new backfield tandem.

Christian McCaffrey and Isaac Guerendo are the only notable returning players in 2025. The rest of the depth chart is rounded out by rookie Jordan James and undrafted free agent Corey Kiner.

Plus, Christian McCaffrey and Isaac Guerendo are always a question mark given their injuries from last season. Kiner could end up finding himself aligned to carve out a role for himself.

"Isaac Guerendo did a decent job in spot duty last season, earning a 67.2 PFF rushing grade. The team also added fifth-round rookie Jordan James, who recorded an elite 95.7 PFF rushing grade over ...

San Francisco 49ers quarterback Mac Jones (10) takes part in a practice on Thursday, May 29, 2025, in Santa Clara, Calif. (Dai Sugano/Bay Area News Group) ...