49ers' Isaac Guerendo: On field for OTAsGuerendo (knee/ankle) was an active participant at voluntary OTAs, per the 49ers ' official site. Guerendo sustained MCL and ankle sprains in his left leg ...

Isaac Guerendo made an impression during his 2024 rookie campaign, averaging five yards per carry while stepping up after injuries depleted the San Francisco 49ers' running back room.

• Running back: Shanahan praised 2024 rookie Isaac Guerendo, whose late-season emergence prompted the 49ers to trade Jordan Mason to the Minnesota Vikings for a fifth-round pick.

Isaac Guerendo has shown flashes of potential. In his rookie season, he posted 84 rushing attempts for 420 yards (5.0 yards per carry) with four rushing touchdowns.

If McCaffrey is unable to get the green light to start the season, the offense has experienced ball carriers to contribute. Jordan Mason, Isaac Guerendo, Patrick Taylor Jr. and Juszczyk.

Rookie running back Isaac Guerendo was injured early in the first quarter on his second carry of the game. Guerendo suffered knee and ankle injuries after getting rolled up on during a run up the ...

By Sterling Bennett Updated Jan 5, 2025 at 9:55pm Getty San Francisco 49ers' running back Isaac Guerendo is carted off the field after an injury during the first quarter against the Arizona Cardinals ...

Isaac Guerendo #31 of the San Francisco 49ers is carted off the field after an injury during the first quarter against the Arizona Cardinals at State Farm Stadium on Jan. 05, 2025 in Glendale ...

San Francisco 49ers running back Isaac Guerendo gave a positive update on his knee injury Monday, noting he did not tear his ACL as some had speculated: The rookie was carted off the field in the ...

49ers rookie RB Isaac Guerendo has a foot injury and is listed as questionable for Thursday's game against the Rams. Despite this, he is expected to play through the injury, as per ESPN's Adam ...

49ers running back Isaac Guerendo is active on Thursday night against the Rams despite his sprained foot. The 49ers also activated Dre Greenlaw (Achilles) off PUP.