The 49ers also have intriguing depth behind their All-Pro back. Second-year running back Isaac Guerendo stepped up in 2024, filling in admirably while McCaffrey and Jordan Mason battled injuries.

Pro Football Hall of Famer Isaac Bruce, who spent 13 seasons with the St. Louis Rams, still maintains strong ties to the St. Louis area and remains committed to giving back to the St. Louis communi… ...

Isaac Guerendo is a fantasy football sleeper and undervalued draft pick for 2025. Read the fantasy football outlook and draft advice for the San Francisco 49ers running back.

Arellanes currently portrays Isaac Garcia in Netflix’s hit YA series My Life with the Walter Boy s, which will premiere its second season in August, and will appear in the upcoming feature Wind ...

Guerendo, who got one carry those first three games McCaffrey was back, eventually ended his rookie season getting carted off Arizona’s field with an MCL injury.

Williams did not take part in team drills last Thursday. 7. Christian McCaffrey/Isaac Guerendo This is essentially a brand-new backfield tandem.

San Francisco 49ers quarterback Mac Jones (10) takes part in a practice on Thursday, May 29, 2025, in Santa Clara, Calif. (Dai Sugano/Bay Area News Group) ...

San Francisco 49ers quarterback Mac Jones (10) takes part in a practice on Thursday, May 29, 2025, in Santa Clara, Calif. (Dai Sugano/Bay Area News Group) ...

Williams did not take part in team drills last Thursday. 7. Christian McCaffrey/Isaac Guerendo This is essentially a brand-new backfield tandem.

Williams did not take part in team drills last Thursday. 7. Christian McCaffrey/Isaac Guerendo This is essentially a brand-new backfield tandem.