At 7-9 on the season, a win against Jacksonville in Week 18 could see the Colts stay put at their current draft slot or even drop a few selections. A loss, however, and they could move up a spot or two depending on what else happens around the NFL.

The Jacksonville Jaguars (4-12) are 4.5-point underdogs in a road AFC South matchup against the Indianapolis Colts (7-9) on Sunday, January 5, 2025 at Lucas Oil Stadium.NFL odds courtesy of BetMGM

Facing a remarkable chance to remain in the playoff race until the final week of the season, the Colts instead came out flat, mistake-prone and overmatched against the NFL's worst team, dropping a 45-33 decision to a woeful New York Giants team that had lost its last 10 games and seemed destined for the No. 1 pick in the NFL draft.

Strangely, vibes are much better on the sidelines of the 4-12 team than the one at 7-9. While a loss is better for the Jaguars' chances at getting a top-five pick — even the first pick is still an outside shot — they are not playing with that mentality. Even if the Colts sneak out a victory here, it will not be by more than five points.

After compiling a 4-12 record with one game to go, the Jaguars are assured to have one of the earliest selections in the 2025 NFL Draft. Jacksonville Jaguars future: Does anyone know fates of Doug Pederson,

Where could the New Orleans Saints be picking after Week 18? Win or lose, here’s how the 2025 NFL draft order could shake up after the final whistle:

Las Vegas and New York could use a new QB, and both Cam Ward (Miami) and Shedeur Sanders (Colorado) are expected to go early in the draft. Now it's unclear if either will be around by the time those teams pick.