Dr. Brown added, “One of the biggest challenges in treating plexiform neurofibromas associated with NF1 is ensuring that patients remain on MEK inhibitor therapy over the long-term.

Globally, NF1 affects approximately 1 in 3000 individuals. Plexiform neurofibromas (PN), a subtype of NF1-associated tumors, occur in up to 50% of patients with NF1.

Session ID: 2025-06-17:dd3b755dc09d97d6a425c572 Player Element ID: vjs_video_3 ...

Overall, 53 of 114 patients met response criteria, defined as ≥20% reduction in target plexiform neurofibroma (PN) volume on consecutive MRI scans. Responses occurred in 24 of 58 adults and 29 ...

Neurofibromatosis type 1 (NF1) is an autosomal-dominant genetic condition caused by loss-of-function variants in the NF1 gene, 1, 2 with a birth incidence of approximately 1 per 2,500. 3 NF1 variants ...

SpringWorks Therapeutics, Inc. Fri, May 23, 2025, 8:00 AM9 min read ...

A rare genetic disorder known as Neurofibromatosis type one, or NF1, affects about one in 2,500 people in the U.S. That's about 120,000 people. Of those, half will develop a subtype--plexiform ...

Her research interests are focused on improving outcomes for children with tumors associated with neurofibromatosis type 1 (NF-1). She is a co-investigator on two clinical trials involving 1.

Based on: The Treatment of Cavernous and Plexiform Angiomata by the Injection of Boiling Water (Wyeth Method). By Francis Reder, M.D., F.A.C.S. St. Louis: C. V. Mosby Company. 1918. Select the ...

The article by Moertel et al entitled “ReNeu: A Pivotal, Phase IIb Trial of Mirdametinib in Adults and Children With Symptomatic Neurofibromatosis Type 1-Associated Plexiform Neurofibroma” (J Clin ...