Injuries have been running amock for the San Francisco 49ers this season. It started with running back Christian McCaffrey ...

The San Francisco 49ers will likely be without All-Pro tight end George Kittle for Sunday's game against the Los Angeles Rams ...

Injuries are piling up for the 49ers as they gear up for a critical showdown against the Rams. Head coach Kyle Shanahan ...

The recent retirement of Aaron Donald, the three-time Defensive Player of the Year and a key figure in the Rams' defense, has ...

Pollard has played well this season, ranking as RB12 in PPR scoring with 33 carries for 144 yards and a touchdown, adding eight receptions on 10 targets. The Packers have been susceptible to the run, ...

San Francisco 49ers' George Kittle is listed as doubtful for Sunday's game against the Rams. He joins Christian McCaffrey and ...

The San Francisco 49ers (1-1) are visiting the Los Angeles Rams (0-2) on Sunday afternoon in a rivalry game between NFC West ...

The 49ers need a backup running back. That's why they traded up for Isaac Guerendo in Round 4 this year. Just in case someone gets injured. And currently, both ...

With Joe Mixon and Dameon Pierce missing practice all week, Cam Akers is set to be the Texans' RB1 on Sunday in a matchup against his former team. Akers, who was with the Vikings last season, is in ...

Speaking to NBC Sports Bay Area's Greg Papa on "49ers Game Plan," Kyle Shanahan explained why the offense won't change ...

San Francisco 49ers quarterback Brock Purdy will be tested in the coming weeks with the absence of key offensive weapons.

What to look for from the top 49ers and Rams players and how to watch the game as they face off on Sunday, week 3.